Polarisome assembly mediates actin remodeling during polarized yeast and fungal growth

ABSTRACT Dynamic assembly and remodeling of actin is critical for many cellular processes during development stress adaptation. In filamentous fungi budding yeast, cables align in a polarized manner along the mother-to-daughter cell axis, are essential establishment maintenance polarity; moreover, they rapidly remodel response to environmental cues achieve an optimal system response. A formin at tip region within macromolecular complex, called polarisome, responsible driving cable polymerization polarity establishment. This polarisome undergoes dynamic through spatial temporally regulated interactions between its components. Understanding this process important comprehend tuneable activities formin-centered nucleation core, which divergent molecular modes polarisome. Review, we focus on how intrinsically disordered regions (IDRs) orchestrate condensation components complex. addition, address these dynamically distributed out zone, thereby regulating growth. We also discuss potential mechanical feedback mechanisms by force-induced yeast regulates function